TP53 Exon 5 Mutation Indicates Poor Progression-Free Survival for Patients with Stage IV NSCLC

TP53 Exon 5 Mutation Indicates Poor Progression-Free Survival for Patients with Stage IV NSCLC

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Background: Genetic mutations are quite common in non-small cell lung cancer (NSCLC), however, their prognostic value remains controversial.Methods: This study explored the mutational landscape of tumor samples from patients with advanced NSCLC by next-generation sequencing (NGS).A total of 101 NSCLC patients in stage III or IV receiving first-line treatment were included.Results: TP53 mutation was the most frequent genetic alteration in NSCLC tumors (68%), followed by EGFR (49%), CDKN2A (12%), LRP1B (9%), and FAT3 (9%) mutations.Among 85 patients with stage IV NSCLC, first-line targeted therapy remarkably prolonged progression-free survival (PFS) The Development of Knowledge Enrichment Books Concerning Ice and Snow Physical Studies for High-School Students of patients compared with first-line chemotherapy (p = 0.

0028).Among 65 patients with stage IV NSCLC whose tumors harbored EGFR, ALK, ROS, or BRAF mutations, first-line targeted therapy substantially prolonged the PFS of patients (p = 0.0027).In patients with TP53 mutations who received first-line targeted therapy or chemotherapy, missense mutation was the most common mutation type (36/78), and exon 5 represented the Comparison of Early Childhood Asthenopia Levels Between Traditional Marsitekka or Engklek Guess The Picture Games and Digital Games most common mutated site (16/78).Conclusions: TP53 mutation in exon 5 could independently predict poor PFS of patients with stage IV NSCLC after the first- line treatment.

Moreover, mutations in TP53 exon 5 and LRP1B were associated with shorter PFS of such patients whether after first-line chemotherapy or targeted therapy, respectively.Thus, these patients should be given immunotherapy or immunochemotherapy.